یکشنبه, 03 آبان 1394 ساعت 21:54

رادیوتراپی سه بعدی کانفورمال( ۳DCRT )

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کلینیک امید تهران: این نوع رادیوتراپی فرآیند پیچیده ای است که با خلق مجموعه ای از داده های سه بعدی از تومور و بافت های سالم آغاز می شود. بعد از آن، از این مجموعه برای ایجاد تصاویر سه بعدی کامپیوتری و طراحی نقشه های پیچیده استفاده می شود تا بتوان پرتو را به صورت متمرکز به تومور تابانید و بافت های سالم اطراف آن را حفظ نمود. در این روش در حالی که بافت های سالم اطراف اشعۀ کمتری می گیرند، می توان دوز بیشتری را به سلول های سرطانی رساند؛ در نتیجه، این تکنیک با عوارض جانبی کمتر، تومور را بیشتر تحت کنترل در می آورد.

از ۳DCRT برای درمان تومورهایی که نزدیک به ارگان های حساس و حیاتی هستند، استفاده می شود. به عنوان مثال می توان از آن برای رساندن دوز مناسب به تومورهای سر و گردن استفاده کرد در حالی که میزان تابش به نخاع، عصب چشم و غدد بزاقی و سایر ارگان های مهم به نسبت تکنیک های پیشین، خیلی کمتر شده است.

شروع درمان با ۳DCRT با یک شبیه سازی مجازی از بدن به کمک سی تی اسکن از ناحیۀ مورد نظر، است. این شبیه سازی مجازی، یک فایل ثابت دیجیتالی ایجاد می کند که تمام اجزای گروه می توانند برای طراحی یک درمان به صورت اختصاصی برای یک فرد به آن دسترسی داشته باشند.

بعد از آن، پزشک با نرم افزار مخصوص طراحی درمان، تصاویری که به کمک سی تی اسکن از ناحیۀ مورد نظر گرفته شده است را بررسی می کند، به این صورت می تواند ناحیۀ مورد نظر را به صورت سه بعدی مشاهده کند. با این قابلیت می توان در حالی که بافت های اطراف بهتر حفظ می شوند، شدت و جهت تابش پرتوها به تومور را با دقت بیشتری تعیین کرد. پزشکان این اطلاعات را وارد سیستمی که مسئول درمان است می کنند.

رادیوتراپی به کمک شتابدهنده های خطی درمانی، که در فواصل کوتاه از انرژی های زیاد برای شتاب دادن الکترون ها تا حدود سرعت نور استفاده می شود، انجام می شود. وقتی الکترون ها به حداکثر سرعت ممکن می رسند، با هدفی از جنس تنگستن برخورد می کنند، که در نتیجه این هدف باعث انتشار اشعۀ ایکس به صورت متمرکز به ناحیۀ مورد نظر می شود. وقتی پرتو وارد بافت های بدن انسان می شود یون های پر انرژی تولید می کند که برای هر دو دستۀ سلول های سرطانی و سالم کشنده هستند. سلول های سالم به مرور نسبت به آن سازگار می شوند ولی سلول های سرطانی نمی توانند با آن وفق پیدا کنند. علاوه بر آن، از آن جا که سلول های سرطانی نسبت به سلول های سالم سریعتر تقسیم و تکثیر می شوند، حساسیت بیشتری دارند. در نتیجه این درمان در جلسات متوالی انجام می شود تا در یک جلسه و با دوز زیاد که بسیار مخرب است.

بعد از انجام معاینات فیزیکی و گرفتن شرح حال، اُنکولوژیست برای هر بیمار درمان خاصی را در نظر می گیرد. اُنکولوژیست در ارتباط نزدیک با سایر پزشکان و افراد تیم مانند پرستار، فیزیسیست، دوزیمتریست و رادیوتراپیست می باشد. فیزیسیست و دوزیمتریست، چگونگی تنظیمات پرتو و میزان دزی که باید تابیده شود را طراحی می کنند.

در بیشتر موارد، ۳DCRT با یک جلسه ” شبیه سازیِ مجازی” که در حدود ۹۰- ۳۰ دقیقه طول می کشد آغاز می شود. این جلسه معمولاً شامل یک سی تی اسکن برای طراحی درمان، تهیۀ قالب های خاص برای ثابت و یکسان نگه داشتن بدن بیمار در تمام جلسات درمانی و قرار دادن تتو هایی رنگی به اندازۀ ۳میلیمتر روی پوست به منظور کمک به تنظیم درمان رادیوتراپی روی ناحیۀ هدف می شود. در ادامۀ آن حدود ۳ تا ۷ روز طول می کشد تا تیم یک درمان را طراحی کند، بعد از آن ملاقاتی با بیمار صورت می گیرد تا درمان شروع شود.

یک درمان معمول رادیوتراپی در حدود ۱۵ تا ۳۰ دقیقه طول می کشد، هر چند ممکن است اولین جلسۀ درمان که همۀ موارد دوباره بررسی می شوند، کمی بیشتر طول بکشد. در اتاق درمان، رادیوتراپیست از علامت های روی پوست برای تعیین محل هدف درمان استفاده می کند. بدن بیمار روی تخت تنظیم می شود و گاهی از قالبی که در جلسۀ آمادگی درست شده است، استفاده می شود. بعد از آن رادیوتراپیست اتاق درمان را ترک می کند و دستگاه را روشن می کند. رادیوتراپیست، دستگاه را از یک اتاقِ فرمان روشن می کند، او در این اتاق می تواند بیمار را از طریق مانیتورهایی که وجود دارد ببیند و با او صحبت کند.

تابش پرتو بدون درد است، مانند زمانی است که بیمار تحت تصویربرداری با پرتوایکس قرار می گیرد. بیماران پرتو را نمی بینند، صدایی نمی شنوند و معمولاً چیزی احساس نمی کنند. اگر بیمار به هر دلیلی دچار ناراحتی یا مشکلی شود، رادیوتراپیست می تواند درمان را قطع کند.

رادیوتراپی معمولاً در جلسات کوتاه مدت در ۵ جلسه در هفته به مدت ۶ یا ۷ هفته متوالی انجام می شود. دوز های کم و فواصل بین جلسات به سلول های سالم ناحیۀ درمانی کمک می کند تا بازسازی شوند. کل دوز درمانی و تعداد جلسات درمانی که بیمار نیاز دارد به اندازه و محل تومور، نوع تومور، سلامت کلی بیمار و سایر عوامل بستگی دارد.

 

 

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