سه شنبه, 28 مهر 1394 ساعت 18:30

سرطان استخوان

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کلینیک امید تهران: استخوان ها به عنوان چهارچوب ساپورت بدن، سازه ای را تشکیل می دهند و شکل بدن را می سازند که این خود به مانند نگهدارنده ای برای ماهیچه ها برای ایجاد حرکت است و نیز از ارگان های درونی بدن حفاظت می کند
بیشتر استخوان ها توخالی هستند و از یک بخش سخت بیرونی (که ترکیبات کلسیم در آن رسوب می کند)، یک بافت داخلی اسفنجی که مغز استخوان را نگه می دارد (که یاخته های خونی را می سازد و نیز آنها را ذخیره می کند) و غضروف در هر سر استخوان که به مانند بالشتکی در بین استخوان ها عمل می کند)، تشکیل شده اند. خود استخوان سه نوع یاخته دارد: یاخته استخوان ساز، یاخته osteocyte که به نگهداری استخوان کمک می کند و یاخته osteoclasts که استخوان را تقسیم بندی می کند.
سرطان  استخوان، سرطان  نادری است که در درون یاخته های استخوانی شکل می گیرد و متاسفانه اکثرا در گروه سنی نوجوان و جوان و بین 10 الی 30 سالگی شایع می باشد. نسبت ابتلا در دختران و پسران مساوی می باشد. شایع ترین محل بروز تومور در اطراف زانو، اطراف شانه و لگن خاصره می باشد.
علل سرطان استخوان به وضوح مشخص نیست. پزشکان تصور می کنند که سرطان استخوان از یک خطا در DNA سلول ناشی می شود. این نقص سبب می شود رشد و تقسیم سلولی از کنترل خارج شود، لذا این سلول ها در زمان تعیین شده از بین نرفته و به بقاء خود ادامه می دهند. توده ی تجمع یافته از سلول های جهش یافته، توده (تومور) را تشکیل می دهند که می تواند به ساختارهای اطراف حمله کرده و یا به سایر نقاط بدن گسترش یابد.
 طبق نظر انجمن سرطان  آمریکا، سرطان  استخوان اولیه، کمتر از 2/0 درصد از همه سرطان‌ها را تشکیل می‌دهد(سرطان  اولیه)، به گونه ای که در ایالات متحده، فقط حدود 2300 مورد جدید وجود دارد. این سرطان  اغلب در استخوان های بلند بازو و ساق پا به وجود می آید.
اما اکثر بدیخیمی های استخوان از نوع ثانویه هستند چراکه معمولا استخوان ها مکان تومورهایی هستند که از بخش دیگری از بدن به استخوان گسترش یافته اند: مانند سینه، ریه ها و پروستات. به عبارتی این نوع سرطان متاستازی از سرطانهای دیگر است.

انواع سرطان  اولیه استخوان
Osteosarcoma- به عنوان تومور بدخیم osteogenic هم شناخته می شود. Osteosarcoma ، شایع ترین سرطان  استخوان است و معمولا در استخوان های بازو، ساق پا و یا لگن خاصره و در سنین بین 10 و 30 سالگی شروع می شود.
 Chondrosarcoma- این نوع از سرطان  استخوان، در یاخته های غضروفی شکل می گیرد و دومین سرطان  شایع استخوان است. این سرطان  در سنین زیر 20 سالگی رخ می دهد و احتمال ابتلاء به آن با افزایش سن کم می شود.
تومور Ewing- به عنوان تومور بدخیم Ewing هم شناخته می شود. این سرطان  در استخوان ها شروع می شود اما می تواند در دیگر بافت ها و در عضلات هم آغاز شود. این سرطان ، سومین سرطان  شایع استخوان است و معمولا در بدن کودکان و نوجوانان شکل می گیرد. Fibrosarcoma و malignant fibrous histiocytoma- هر دو نوع این سرطان  ها در بافت نرم اطراف استخوان بوجود می آید و بیشتر در افراد بزرگسال دیده می شود. این دو نوع سرطان  بر روی بازوها، ساق پا و فک اثر می گذارد.
تومور یاخته ای غول پیکر استخوان- این نوع سرطان  استخوان می تواند هم به شکل خوش خیم باشد و هم بدخیم که البته نوع خوش خیم آن، شایع تر است. این سرطان ، بر بازو و یا ساق پا اثر می گذارد، در سنین میانسالی رخ می دهد و گسترشی ندارد. این سرطان  پس از برداشتن توسط جراحی، دوباره برمی گردد و گرایش به این دارد که به بخش های دیگر بدن نیز گسترش یابد.
Chordoma- اغلب در بین افراد 30 ساله و یا بیشتر از آن دیده می شود. این نوع سرطان  استخوان بر ستون فقرات و جمجمه اثر می گذارد. این سرطان  در بین مردان دو برابر زنان است و بدون این که گسترش یابد، رشد می کند. پس از جراحی، این نوع سرطان  استخوان برمی گردد و معمولا به ریه ها، کبد و غدد لنفاوی گسترش می یابد.
 

 

خواندن 3495 دفعه آخرین ویرایش در شنبه, 07 آذر 1394 ساعت 18:09
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